NOSIP overexpression promotes long-term persistence of CD8<sup>+</sup> T cells during chronic infection.

Although the frequency of CX3CR1 neg cells showed only a modest upward trend, cell number analysis revealed a significant expansion of the CX3CR1 neg population, with CX3CR1 int cells also exhibiting an increasing trend and CX3CR1 hi cells maintained at comparable levels under anti-PD-L1 antibody treatment ( Supplementary Figure 9C ).

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