Development and validation of a green dispersive liquid-liquid microextraction-LC-MS/MS method for sotalol quantification in human plasma using central composite design optimization and pharmacokinetic application.

ANOVA demonstrated highly significant models for both responses (F = 130.35 and 92.02, respectively; p < 0.0001), with extraction solvent volume exerting the most pronounced influence on recovery (F = 315.12), followed by pH (F = 225.51) and disperser volume (F = 151.42) (Table 1 ).

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