Bifidobacterium infantis-mediated HSV-TK/GCV therapy modulates the tumor microenvironment through site-specific phosphorylation of HIF-1α, mTOR, and PD-L1.

Pathway and core protein identification Functional and pathway analysis of the significantly altered phosphorylation sites revealed that in the PPI network of total PIPAs across the four groups ( Figure 8A ), 236 GO terms were significantly enriched (FDR < 0.05), and 95 were highly significant (FDR < 0.01).

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