Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2-m6A-Dependent KDR/VEGFA Loop.

Dynamic gene expression analysis along the trajectory revealed that Mettl3 expression showed an increasing trend toward late pseudotime (Figure 1M ). 2.2 METTL3 Depletion Alleviates IL‐17A/Th17 Response and Thyroid Injury To investigate the functional role of METTL3 in AIT, we silenced its endogenous expression in TFCs using shRNAs (Figure 2A ).

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