Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM<sup>+</sup> Cholangiocyte Subcluster via Hypoxia/TGF-β-CREM-VIM Axis.

Bile tissues from patient P6 manifested a more intact morphology, with a decreasing trend in the CREM expression and the degree of EMT and fibrosis (Figure 8C ) after melatonin treatment.

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