Tumor-Specific Delivery of CD28 siRNA via Lyso-PC C-16 Modified Lipid Nanoparticles Overcomes Anti-PD-1 Resistance by Remodeling Tumor Microenvironment.

Adv Sci (Weinh) · 2026 · PMC13337025 · PMID 42261788

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highly significantno p-value reported

Simultaneously, the tumor cell‐specific transfection efficiency soared from 9.5% in the COM‐LNP group to 16.0% in the LPC‐LNP group, representing a highly significant ∼1.7‐fold localized enhancement.

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