Astrocyte-derived HMGB1 compromises the integrity of the blood-brain barrier through the CaM/CaMKII/AQP4 pathway and the protective function of trifluoperazine.

Front Immunol · 2026 · PMC13337370 · PMID 42416052

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highly significantno p-value reported

Further examination using Gene Ontology (GO) functional enrichment analysis ( Figure 3D ) demonstrated that the top five significantly enriched entries in each functional category were highly significant.

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