TRMT6/61A-mediated tRNA m1A methylation promotes codon-dependent TAB2 translation and drives AML progression.

Mol Med · 2026 · PMC13339324 · PMID 42129624

Europe PMC DOI

hedged sentences

0.3869

closest p · 7.7× alpha

0.3869

boldest claim

The sentences

a positive trendp = 0.3869not close (p > 0.1)

However, while a positive trend was observed, the correlation between TRMT61A and TAB2 mRNA levels in the TARGET-LAML cohort did not reach statistical significance ( r = 0.0674, p = 0.3869; Fig. 6 D).

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highly significantno p-value reported

Although other candidates like CREB5 exhibited greater absolute changes in TE, TAB2 still demonstrates a highly significant intersection of decreased translational efficiency and high m1A-associated codon occupancy (Fig. 5 I and Table S5).

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