The percentage of CD8 T cells was higher in the islets of Cre + - Tnfrsf9 E7fl/fl mice than the Cre + - Tnfrsf9 +/+ control, albeit the magnitude of increase was not as significant as that observed in Cre + - Tnfrsf9 fl/fl mice ( Fig. 6 E ).
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Both soluble and cell surface CD137 expressed by Foxp3+ CD4 T cells restrain autoimmune diabetes.
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