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Multi-responsive tetrahedral DNA frameworks for <i>in situ</i> methyltransferase imaging to distinguish living chemoresistant tumor cells.

Chem Sci · 2026 · PMC13340776 · PMID 42415956

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These observations were quantitatively corroborated by fluorescence intensity analysis, which revealed a more than 3-fold increase in the FAM channel signal in chemoresistant U251 MG/TMZ cells compared to that in U251 cells, with highly significant statistical differences ( P < 0.0001, Fig. 5E ).

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