When CCT2 is downregulated, decreased expression levels are observed in BCL-2, MDM2, CDK2, and Cyclin E; conversely, the expression of BAX, FAS, Caspase 3, CHEK1, and P21 shows an increasing trend.
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CCT2 regulates the proliferation, apoptosis, and cell cycle arrest of multiple myeloma cells through the P53 signalling pathway.
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