Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank.

Figure 1g shows a modest yet highly significant association between DBP and waist circumference across the full cohort (Pearson r = 0.29, p < 1 × 10 − 350 ).

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3 b, d ): top AFR hits became only modestly significant in Europeans, whereas top European hits were almost uniformly non-significant in Africans, with most p-values falling orders of magnitude above genome-wide thresholds despite preserved effect directions.

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