highly significantp < 0.001
Genes were categorized into the following significance levels: highly significant ( p < 0.001 and | log2 FC| > 2), very significant ( p < 0.01 and | log2 FC| > 1.5), significant up ( p < 0.05 and | log2 FC| > 1.0), significant down ( p < 0.05 and log2 FC < -1.0), marginally significant ( p < 0.1), and not significant ( p ≥ 0.1).