From the Gut to the Brain: Modeling Intestinal Absorption and Assessing Blood-Brain-Barrier Permeability of Small-Molecule Drugs by IAM Chromatography.

Although this model shows a marginally significant coefficient ( p < 0.005) for logP in comparison to other descriptors of the model ( p < 0.001) when considered alone, its inclusion is essential because lipophilicity influences both solubility and the ability to partition into the lipid bilayer of the epithelium.

also in 26,082 other papers