While surface-immobilization-based methods have unquestionably yielded highly significant results and continue to evolve, , the immobilization process can disrupt the molecule’s natural dynamics and, in some cases, impede its biological function. − To overcome these limitations, several techniques have been developed in recent years for the longer-term observation of single molecules without immobilization.
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A Nanopore-Gated Subattoliter Silicon Nanocavity for Single-Molecule Trapping and Analysis without Applying an External Force.
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