Barely Significant
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HMGB1-TLR4 signaling-mediated neuroinflammation contributes to the pathogenesis of infantile epileptic spasms syndrome in rats.

Front Neurol · 2026 · PMC13349843 · PMID 42434072

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an increasing trendP >0.05actually significant
The expression of and arginase 1 (Arg1) in the brain tissues of the IESS+NS group and IESS group was significantly lower than that in the BC and NC groups; compared with the IESS+NS group and IESS group, ACTH intervention showed an increasing trend in Arg1 expression with no statistical significance ( P >0.05), while anti-HMGB1 and the combination of ACTH and anti-HMGB1 significantly increased Arg1 expression, with the combination intervention exerting the best effect.

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