Multi-omics profiling of the diabetic human heart reveals coupled dysregulation in lipid metabolism, mitophagy, and extracellular matrix remodeling.

Cell-type Identification by Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) analysis revealed a significantly elevated proportion of M1 macrophages in the DbCM group compared to the non-diabetic CM group, while both disease groups showed a decreasing trend relative to healthy controls (Fig. 1 G).

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