Efficacy of Mavacamten on functional capacity in hypertrophic cardiomyopathy: a meta-analysis, meta-regression, and trial sequential analysis of randomized controlled trials.

Principal findings Our analysis revealed that Mavacamten significantly reduced LVOT gradients across various clinical scenarios, with a pooled MD of −38.28 mmHg for post-exercise gradients and −59.02 mmHg for post-Valsalva gradients, both highly significant ( P < 0.00001).

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