Generation of apical-out nasal organoids to facilitate human respiratory syncytial virus infection and drug screening.

In contrast, the non-optimized method yielded average organoid counts of 498 (donor 1), 248 (donor 2), and 835 (donor 3) and efficiencies of 41.5%, 20.6%, and 69.5%, with donors 1 and 2 displaying highly significant differences between the two conditions ( Figure 2 A).

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