Genome-wide association study identifies and validates genetic variation in the RIG-I/MAVS signaling pathway associated with HIV-related Kaposi sarcoma in children and adults.

Front Oncol · 2026 · PMC13357122 · PMID 42444820

Europe PMC DOI

hedged sentence

0.0060

closest p · 0.1× alpha

0.0060

boldest claim

The sentences

highly significantp = 0.006actually significant

A recessive logistic regression model that assumes two copies of the SNV ( aa ) are required for disease showed a highly significant association between MAVS and KS (OR, 2.2, 95% CI 1.2-3.9; p = 0.006).

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