extremely significantp < 0.0001
On Day 42 after immunization, the antibody titer of the 3D‐LS‐LOOP (T142P&Q153P) group was 1:2 7.67 , ~10 times higher than that of the 3D‐LS‐LOOP (Wt) group (1:2 4.33 ), presenting an extremely significant difference between groups ( p < 0.0001).