Population Pharmacokinetics of Intravenous Infusion of Hydromorphone in Critically Ill Patients Supported by Extracorporeal Membrane Oxygenation.

Importantly, the absence of a decreasing trend in the oxygenator‐associated concentration difference over time further suggests a lack of time‐dependent saturable sequestration, which would otherwise be expected if hydromorphone were sequestered by the circuit material.

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