Comprehensive Safety and Efficacy Evaluation of Immunotherapy Combination Approaches Versus Tyrosine Kinase Inhibitor Monotherapy as First-Line Treatment of Hepatocellular Carcinoma: A Network and Individual Patient Data (IPD) Meta-Analysis.

Cancers (Basel) · 2026 · PMC13359836 · PMID 42449661

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hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

a trend toward significancep = 0.055so close (0.05 < p ≤ 0.1)

Grade 3/4 AEs were most frequent with ICPI plus TKI (69.1%) compared to TKI monotherapy (50.1%) and dual ICPI (32.7%), with a trend toward significance ( p = 0.055).

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