Epigenetic Signatures of Frailty: A Systematic Review, Meta-Analysis, and Network Analysis of the Chemical Exposome.

Regarding the other shared genes, the functional enrichment analysis (via TopGO) using CDC42BPB (CDC42 binding protein kinase beta, with a predominant role in regulating actin cytoskeleton and cellular polarity [ 27 ]), SLC1A5 (Solute Carrier Family 1 Member 5, in charge of carrying neutral amino acids through the cellular membrane [ 28 ]), and SLC22A18AS (Solute Carrier Family 22 Member 18 Antisense, encodes a long non-coding RNA, involved in epigenetic regulation of the gene SLC22A18) revealed highly significant biological processes (adjusted p = 0.0043, fold enrichment = 100), including: L-glutamine import across the plasma membrane (GO:1903803), positive regulation of the vitamin D receptor signaling pathway (GO:0070564), L-aspartate import across the plasma membrane (GO:0140409), L-serine transport (GO:0015825), and glutamine transport (GO:0006868).

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