Integrative metabolite-protein interaction networks reveal potential pathways and biomarkers in sepsis.

BMC Infect Dis · 2026 · PMC13362219 · PMID 42143237

Europe PMC DOI

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highly significantp < 10−8actually significant

Notably, the gene candidates THBS1 and IL18RAP exhibited highly significant upregulation (LogFC > 1.9, p < 10−8) in the independent GSE28750 cohort, confirming that our network-based prioritization captures clinically relevant expression changes.

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