Optimization of Ellagic Acid-Loaded Liposomes Using Box-Behnken Design and the Modulatory Role of Chitosan Molecular Weight on Their Stability, Digestive Release, and Antioxidant Activity.

Multiple regression fitting analysis via Design-Expert 13.0, a second-order polynomial regression equation for the EE (Y), was established as follows: (8) Y = 85.24 + 2.64A + 1.35B + 0.7388C − 0.0700AB − 1.05AC − 0.5225BC − 3.73A 2 − 2.84B 2 − 3.07C 2 As evidenced by the ANOVA results presented in Table 3 , the regression model yielded a p < 0.0001, indicating that the model is highly significant.

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