Thermoresponsive Injectable Self-Healing Hydrogel Loaded with Self-Regenerating Photothermal Agent for Synergistic Photothermal-Thermodynamic-Chemodynamic Therapy for Pancreatic Cancer.

Polymers (Basel) · 2026 · PMC13364316 · PMID 42452077

Europe PMC DOI

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extremely significantp < 0.001actually significant

The tumor size and weight of the H + AB@Cu-MOF + NIR group were significantly lower than those of all other groups with extremely significant differences compared with the control group (*** p < 0.001), which fully proves that AB@Cu-MOF nanocomposite hydrogels can achieve prominent synergistic enhancement of PTT-TDT-CDT under NIR irradiation and greatly improve in vivo anti-tumor efficacy.

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