Plasma metformin concentration as a determinant of metabolic response in adults with type 1 diabetes: a 1-year prospective observational study.

Front Pharmacol · 2026 · PMC13364628 · PMID 42453589

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a decreasing trendno p-value reported

DDI showed a decreasing trend over time, from 0.65 U/kg (IQR 0.52–0.91) at V1 to 0.57 U/kg (IQR 0.42–0.70) at V6, although the overall effect of time did not reach statistical significance (p = 0.0712).

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