Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes.

Mol Psychiatry · 2026 · PMC13364699 · PMID 41935184

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a decreasing trendno p-value reported

Similar to 5xFAD mice, HDAC9 mRNA expression was decreased in the hippocampus of APP/PS1 mice compared to WT littermate controls; a decreasing trend was also observed in the PFC of APP/PS1 mice (Fig. 5B ).

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