American Society of Hematology 2026 guidelines for frontline management of acute lymphoblastic leukemia in adolescents and young adults.

Blood Adv · 2026 · PMC13366240 · PMID 41670627

Europe PMC DOI

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a nonsignificant trendno p-value reported

There is a nonsignificant trend toward lower rates of pre– and post–allo-HSCT relapse rates with RIT plus a TKI than with IC plus a TKI (pre–allo-HSCT RR of 0.26 [95% CI, 0.03-2.18]; post–allo-HSCT RR of 0.65 [95% CI, 0.2-2.11]).

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likely to be significantno p-value reported

The panel highlighted that the consequences of CNS relapse, and its treatment, are likely to be significant and underrecognized.

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