Design and synthesis of new donepezil-based chalcones as multi-target-directed ligands against Alzheimer's disease: biological evaluation, molecular dynamics, and zebrafish model studies.

RSC Adv · 2026 · PMC13367280 · PMID 42453957

Europe PMC DOI

hedged sentence

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantp < 0.001actually significant

Donepezil treatment yielded a highly significant therapeutic effect ( p < 0.001) as compared with the AD group.

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