Hypoxia-induced endoplasmic reticulum stress mediates lenvatinib resistance in hepatocellular carcinoma through the IRE1α-XBP1s-HIF1α pathway.

In addition, after 24 h of cell culture, we placed the cells in the logarithmic phase into a hypoxic incubator and observed that the proliferation of cells under hypoxia showed an increasing trend over time (Fig. 2 G).

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