Soluble Uric Acid Drives CD8+ T-cell Exhaustion by Inducing KSR1-Mediated MAPK Hyperactivation.

Cancer Res · 2026 · PMC13370115 · PMID 42118604

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a nonsignificant trendno p-value reported

Tumor growth showed a nonsignificant trend toward an increase in the high-UA group, with partial reversal of UA-driven tumor progression attributable to Tim-3 deficiency in a subset of immune cells (Supplementary Fig.

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