Understanding how enzymes work: the journey to ensemble-function studies.

FEBS J · 2026 · PMC13370710 · PMID 41705301

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highly significantno p-value reported

This unbiased comparison revealed a highly significant, ~ 15° rotation of the catalytic serine sidechain ( χ 1 ) from the GSA to the TSA‐bound state that brings the reactants ~ 0.3 Å closer to each other, thereby facilitating bond formation (Fig. 4C ).

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