Identification and validation of CNTNAP2/PAX1 hypermethylation as an epigenetic biomarker panel for detection of cervical cancer and precancerous lesions in hrHPV-positive women.

BMC Cancer · 2026 · PMC13371192 · PMID 42174462

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an increasing trendno p-value reported

Next, we analyzed the methylation patterns of these 10 genes across different disease stages (control, CIN1, CIN2, CIN3, and cancer), and identified that the DMRs of 6 of the 10 genes showed an increasing trend in mean methylation during cervical carcinogenesis (Supplementary Figure S5).

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