S100A9 as a shared biomarker and mediator of metabolic dysfunction in peripheral artery disease and sarcopenia.

Front Genet · 2026 · PMC13372276 · PMID 42460156

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantp < 0.001actually significant

Among them, UDP-Glucose exhibited an extremely high VIP value (VIP > 4.5) and a highly significant difference (p < 0.001), suggesting that rS100A9 may affect cellular energy reserves by intervening in the glycogen synthesis pathway.

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a decreasing trendno p-value reported

Specifically, the infiltration proportions of naïve CD4 + T cells, Macrophages M0, Macrophages M2, and Neutrophils were significantly increased, while some immune cell subsets showed a decreasing trend in PAD.

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