Risk factors associated with extended spectrum beta lactamase <i>Klebsiella pneum</i>oniae outbreak in a neonatal intensive care unit.

Although amikacin and teicoplanin use were found to be highly significant in the univariable analysis ( P < .001), in the multivariable model, after adjusting for risk factors and other confounders, the association between amikacin and teicoplanin with the primary outcome attenuated showing only borderline significance ( P = .04 and P = .04, respectively).

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Furthermore, amikacin and teicoplanin attenuated from strong univariate predictors to only borderline significant risk factors for ESBL-KP.

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This marginal significance suggests that while these antibiotics remain relevant, their independent contribution is modest once baseline risk is factored in.

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