Frailty and sarcopenia trajectories yielded highly significant indirect mediating effects of β = 0.11 and β = 0.12, respectively, which translated to substantial mediation proportions of 45.8 and 46.2% of their cumulative risk pathways (both total effects p < 0.001).
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Risk factors and mediating mechanisms of restless legs syndrome in patients undergoing maintenance hemodialysis: a longitudinal cohort study combined with Mendelian randomization analysis.
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