Wound fluid proteomics reveal elevated alpha-1 antitrypsin levels are associated with healing of medical device related pressure injury.

To further validate this relationship whilst accounting for the repeated measures structure of the data, a linear mixed model confirmed a highly significant positive association between A1AT and KNG-1 protein abundance (β = 0.555, SE = 0.081, df = 46.5, t = 6.873, p < 0.001), which remained significant following Bonferroni correction (adjusted threshold p < 0.017; ICC = 0.38).

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