Systematic evaluation and statistical modeling of dual centrifugation and high-pressure homogenization as promising methods for scalable preparation of polymeric nanoparticles.

Statistical analysis and modeling Factorial model validation The statistical analysis of the quadratic models for responses (PS, PDI, and ZP) across the three preparation methods revealed that the selected factors (CPPs) significantly influenced the responses (CQAs), as indicated by the highly significant model p-values ( P < 0.0001).

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