Multi-omics integration predicts the incidence of 17 diseases in the UK Biobank.

We further validated this potential causal relationship using SomaScan pQTLs 47 (Methods), where the weighted median estimator 48 showed significant result (OR = 0.89, 95% CI: 0.81-0.98, p -value = 0.019) while the IVW estimator was close to significance with the same direction of effect (OR = 0.94, 95% CI: 0.87–1.02, p -value = 0.12).

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Besides, a strong enrichment in average total household income and Townsend deprivation index were observed for COPD-associated proteins, which remained highly significant even after considering top proteins in the PANEL-adjusted model (OR = 23.52, 12.94 FDR = 2.52E-9, 6.09E-5, Supplementary Data 13 ).

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