SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism.

Cell Rep · 2026 · PMC13378056 · PMID 42287635

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a decreasing trendno p-value reported

Consistent with enhanced secretion, total cellular NPC2 levels in CoV-2 ORF3a cells showed a decreasing trend compared with other Flp-In cells ( Figures S4A and S4H ).

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