Immune-epithelial crosstalk governs immune checkpoint inhibitor efficacy in colorectal cancer.

iScience · 2026 · PMC13378363 · PMID 42491875

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 3.6e−30actually significant

Specifically, M186 was enriched (Adj p = 3.8e−03) for class-switched memory B cells ( BANK1 , IGHA2 , PAX5 , and SPIB ), whereas M181 showed highly significant enrichment (Adj p = 3.6e−30) for plasma cells ( FCRLA , HERPUD 1, JCHAIN , MZB1 , TNFRSF17 , and multiple V region genes).

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