HNPP: Higher-order network-based personalized PageRank for detecting critical phase in complex biological systems.

Moreover, as shown in Fig 5B , GSVA analysis of signaling genes indicated that the enrichment scores of pathways such as the B cell receptor signaling pathway, Rap1 signaling pathway, Adherens junction, Apoptosis, and MAPK signaling pathway showed an increasing trend during the development of cancer resistance, which may promote erlotinib resistance by enhancing tumor cell proliferation, self-renewal, apoptosis suppression, and adhesion.

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