Outcomes in Patients With Peripheral Arterial Disease With and Without Prior Minor Amputation: A Comparative Analysis.

Cureus · 2026 · PMC13380416 · PMID 42472145

Europe PMC DOI

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highly significantP = 0.001actually significant

For major amputation, PMA emerged as a highly significant protective factor (HR 0.05, 95% CI 0.02-0.18, P = 0.001), indicating that patients with PMA had a 95% lower risk of subsequent major amputation.

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