Combination of polygonatum sibiricum and hedyotis diffusa induces pyroptosis in non-small cell lung cancer cells via the TLR4/NLRP3/Caspase-1/GSDMD pathway: an <i>in vitro</i> and <i>in vivo</i> study using medicated serum and herbal extract.

Front Pharmacol · 2026 · PMC13381225 · PMID 42518350

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highly significantno p-value reported

However, the inhibitory effect of the 3:1 ratio group was extremely significant (P < 0.0001), and even under the most stringent Bonferroni correction (corrected threshold P < 0.0056), the difference remained highly significant.

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Combination of polygonatum sibiricum and hedyotis diffusa induces pyroptosis in non-small cell lung cancer cells via the TLR4/NLRP3/Caspase-1/GSDMD pathway: an &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; study using medicated serum and herbal extract.

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Combination of polygonatum sibiricum and hedyotis diffusa induces pyroptosis in non-small cell lung cancer cells via the TLR4/NLRP3/Caspase-1/GSDMD pathway: an <i>in vitro</i> and <i>in vivo</i> study using medicated serum and herbal extract.