Phosphatidylethanolamine binds to human perilipins via a hydrophobic cleft in their 4-helix bundle domain for lipid droplet targeting.

J Biol Chem · 2026 · PMC13382019 · PMID 42320629

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a decreasing trendno p-value reported

Full-length PLIN3 and its cleft mutants showed a decreasing trend in binding affinity, though these differences were not statistically significant.

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