"Behavioral and Neuroinflammatory Evaluation of a Novel Isoxazole-5-One Derivative in Animal Models of Alzheimer's Disease via TNF-α, COX-2, IL-6, and NF-κB Modulation".

ACS Omega · 2026 · PMC13382720 · PMID 42518426

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highly significantno p-value reported

The donepezil (3 mg/kg) treatment produced a significant restoration of the performance rate as the mice reversed at an alternation rate, (58.2 ± 3.1%, p < 0.001) compared with scopolamine) proving highly significant as an indication of reversal of scopolamine induced cognitive impairment.

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