Integrated multiomic profiling reveals 2 distinct splenic marginal zone lymphoma subgroups with prognostic relevance.

Blood Adv · 2026 · PMC13383228 · PMID 42200578

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closest p · 1.2× alpha

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boldest claim

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a nonsignificant trendP = .06so close (0.05 < p ≤ 0.1)

In contrast, SMZL-LR was significantly associated with high IGHV mutational load (<97% germ line identity; P < .001; Figure 3 C) and showed a nonsignificant trend toward trisomy 12 ( P = .06).

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