scTIDE: Deciphering Critical Transitions Through Cell-Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching.

As shown in Figures 6E and 6D , the GSVA scores for pathways such as Spindle assembly checkpoint signaling, Beta oxidation acyl coa synthesis, and Tight junction actin signaling pathway exhibits an upward trend before the onset of cell fates, while pathways including Aab7 regulated microtubule minus end directed transport, Microtubule rhoa signaling pathway, and Gh jak stat signaling pathway shows a decreasing trend prior to cell fate specification.

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